With the Repentance DLC loaded, the consumable – will not consume single use active items such as Pandora’s Box, meaning you can consume the card to gain a reward for the current floor without consuming Pandora’s Box.
The Afterbirth passive item – does not double the reward gained from using Pandora’s Box, no matter what floor you’re on.
When on an XL Floor because of Curse of the Labyrinth, refer to the first floor of your current chapter.
Keep in mind your active item slot will be occupied by the box until you leave it behind or use it, so unless you have the – passive item or use the –, you won’t be able to keep any other active items when doing this method. This means you can carry the box with you to future floors if you wish to take advantage of a certain floor’s effects, all of which are listed in the section below.
It will spawn a different combination of pickups or pedestal items depending on what your current floor and chapter are (you can hold tab to see what the current stage is called Basement I, Utero II, Cathedral, etc.).
Its one-time use nature means it will disappear after the first use, so decide carefully when to open it up! It is unlocked by beating Dark Room as Lazarus for the first time, and once unlocked, it will show up in the Red Chest and Shop item pools on future runs as well in as the Greed/Greedier mode shops.
– is a one-time use item that takes up the Active slot.
The basics of Pandora’s Box (if you’re already familiar with the item, you can skip this)
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